Monounsaturated fatty acids are substrates for aldehyde generation in tellurite-exposed Escherichia coli

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dc.contributor.authorPradenas, G.
dc.contributor.authorDíaz-Vásquez, W.
dc.contributor.authorPérez-Donoso, J.
dc.contributor.authorVásquez, C.
dc.date.accessioned2023-04-12T19:48:52Z
dc.date.available2023-04-12T19:48:52Z
dc.date.issued2013
dc.descriptionIndexación: Scopus.
dc.description.abstractReactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial resistance to oxidative stress elicitors was evaluated. Studies included wild-type cells as well as cells exhibiting a modulated monounsaturated fatty acid (MUFA) ratio. The hydroxyaldehyde 4-hydroxy 2-nonenal was found to be most likely produced by E. coli, whose levels are dependent upon exposure to oxidative stress elicitors. Aldehyde amounts and markers of oxidative damage decreased upon exposure to E. coli containing low MUFA ratios, which was paralleled by a concomitant increase in resistance to ROS-generating compounds. MUFAs ratio, lipid peroxidation, and aldehyde generation were found to be directly related; that is, the lower the MUFAs ratio, the lower the peroxide and aldehyde generation levels. These results provide additional evidence about MUFAs being targets for membrane lipid oxidation and their relevance in aldehyde generation.es
dc.description.urihttps://www.hindawi.com/journals/bmri/2013/563756/
dc.identifier.citationBioMed Research International, Volume 2013, 2013, Article number 563756es
dc.identifier.doi10.1155/2013/563756
dc.identifier.issn2314-6141
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48485
dc.language.isoenes
dc.publisherHindawies
dc.rights.licenseAttribution 3.0 Unported (CC BY 3.0)
dc.rights.urihttps://www.hindawi.com/journals/bmri/2013/563756/#copyright
dc.subjectAldehydeses
dc.subjectEscherichia colies
dc.subjectFatty Acidses
dc.subjectMonounsaturatedes
dc.subjectMembrane Lipidses
dc.subjectOxidation-Reductiones
dc.subjectOxidative Stresses
dc.subjectReactive Oxygen Specieses
dc.subjectTelluriumes
dc.titleMonounsaturated fatty acids are substrates for aldehyde generation in tellurite-exposed Escherichia colies
dc.typeArtículoes
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