A new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Perú
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Archivos
Fecha
2014-07
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Medknow Publications
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Background: Azorella compacta is a rare yellow‑green compact resinous cushion shrub
growing from the high Andes of southern Perú to northwestern Argentina, and which is
a producer of biologically active and unique diterpenoids. Objective: This study investigated
the secondary metabolites present in a Peruvian sample of Azorella compacta and the
evaluation of gastroprotective activity of the isolated compounds in a gastric‑ induced ulcer
model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1‑6) present
in the dichloromethane (DCM) extract of A. compacta growing in Perú were isolated by a
combination of Sephadex LH‑20 permeation and silica gel chromatography and their chemical
structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The
gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH‑induced
gastric lesion model in mice and compared to the activity showed by the known compounds.
Results: A new mulinane diterpene along with five known diterpenoids have been isolated
from a Peruvian sample of A. compacta and the gastroprotective results show that compound
1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta
growing in Perú showed the presence of the new mulinane 1, which was poorly active in the
HCl/EtOH‑induced gastric lesion model in mice. Indeed, the activity was lower than other
diterpenoids (2‑6) showing an oxygenated function at C‑16 or/and C‑20, which confirm
the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of
mulinane compounds.
Notas
Indexación: Scopus.
Palabras clave
Apiaceae, Azorella Compacta, Diterpenoids, Gastroprotective Activity, Mulinanes
Citación
Pharmacognosy Magazine. Volume 10, Issue 39, Pages S543 - S548. 1 July 2014
DOI
10.4103/0973-1296.139807