A new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Perú

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dc.contributor.authorSalgado, Francisco
dc.contributor.authorAreche, Carlos
dc.contributor.authorSepúlveda, Beatriz
dc.contributor.authorSimirgiotis, Mario J.
dc.contributor.authorCáceres, Fátima
dc.contributor.authorQuispe, Cristina
dc.contributor.authorQuispe, Lina
dc.contributor.authorCano, Teresa
dc.date.accessioned2023-07-13T22:19:31Z
dc.date.available2023-07-13T22:19:31Z
dc.date.issued2014-07
dc.descriptionIndexación: Scopus.es
dc.description.abstractBackground: Azorella compacta is a rare yellow‑green compact resinous cushion shrub growing from the high Andes of southern Perú to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric‑ induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1‑6) present in the dichloromethane (DCM) extract of A. compacta growing in Perú were isolated by a combination of Sephadex LH‑20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH‑induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Perú showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH‑induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2‑6) showing an oxygenated function at C‑16 or/and C‑20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.es
dc.description.urihttps://phcog.com/article/view/2014/10/39s/s543-s548
dc.identifier.citationPharmacognosy Magazine. Volume 10, Issue 39, Pages S543 - S548. 1 July 2014es
dc.identifier.doi10.4103/0973-1296.139807
dc.identifier.issn0973-1296
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51664
dc.language.isoenes
dc.publisherMedknow Publicationses
dc.subjectApiaceaees
dc.subjectAzorella Compactaes
dc.subjectDiterpenoidses
dc.subjectGastroprotective Activityes
dc.subjectMulinaneses
dc.titleA new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Perúes
dc.typeArtículoes
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