SYNTHESIS OF GERANYLHYDROQUINONE DERIVATIVES WITH POTENCIAL CYTOTOXIC ACTIVITY

Vista sencilla de ítem
dc.contributor.authorBaeza, Evelyn
dc.contributor.authorCatalan, karen
dc.contributor.authorPeña-Cortes, Hugo
dc.contributor.authorEspinoza, Luis
dc.date.accessioned2014-01-29T13:58:09Z
dc.date.accessioned2016-05-24T20:28:34Z
dc.date.available2014-01-29T13:58:09Z
dc.date.available2016-05-24T20:28:34Z
dc.date.issued2012
dc.descriptionIndexación: Web of Science; Scieloes
dc.description.abstractNatural geranylhydroquinone 1 and geranyl-p-methoxyphenol 2 were prepared by Electrophilic Aromatic Substitution (EAS) reactions between geraniol and 1,4-hydroquinone or p-methoxyphenol respectively, using BF3∙Et2O as a catalyst. Furthermore, natural geranylquinone 3, geranyl-1,4-dimethoxyquinone 4 and the new geranyl-4-methoxyphenyl acetate 5 were obtained by chemical transformations of 1 and 2. The compounds were evaluated for their in vitro cytotoxicity activities against cultured human cancer cells of PC-3 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma, and Dermal Human Fibroblasts DHF. IC50 values were in the µM range.es
dc.description.urihttp://ref.scielo.org/zfnxqf
dc.identifier.citationQuím. Nova vol.35 no.3 São Paulo 2012es
dc.identifier.issn0100-4042
dc.identifier.otherDOI: http://dx.doi.org/10.1590/S0100-40422012000300015
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2348
dc.language.isoenglishes
dc.publisherSociedade Brasileira de Químicaes
dc.subjectNatural geranylhydroquinonees
dc.subjectElectrophilic Aromatic Substitutiones
dc.subjecthydroquinone or p-methoxyphenoes
dc.subjectSYNTHESISes
dc.subjectCytotoxic activityes
dc.titleSYNTHESIS OF GERANYLHYDROQUINONE DERIVATIVES WITH POTENCIAL CYTOTOXIC ACTIVITYes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Baeza_Synthesis+of+geranylhydroquinone+derivatives+with+potencial+cytotoxic+activity+_2012.pdf
Tamaño:
3.15 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO INGLES
Descargar
Bloque de licencias
Mostrando 1 - 2 de 2
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista