A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
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Archivos
Fecha
2020-08
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
BioMed Central Ltd
Nombre de Curso
Licencia CC
Attribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/
Resumen
Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. © 2020 The Author(s).
Notas
Indexación: Scopus.
Palabras clave
COVID-19, Lung strain, Mechanical ventilation, P-SILI, SARS-CoV2, Work of breathing
Citación
Critical Care Open Access Volume 24, Issue 110 August 2020 Article number 494
DOI
10.1186/s13054-020-03197-7