Bookmarking the genome: Maintenance of epigenetic information
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Date
2011-05
Profesor/a GuÃa
Facultad/escuela
Idioma
en
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Nombre de Curso
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Attribution 4.0 International (CC BY 4.0)
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Abstract
Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
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Indexación: Scopus.
Keywords
Mitosis, Chromatin, Bookmarking
Citation
Journal of Biological Chemistry, Volume 286, Issue 21, Pages 18355 - 18361, 27 May 2011
DOI
10.1074/jbc.R110.197061