Systemic and pulmonary inflammation/Oxidative damage: Implications of general and respiratory muscle training in chronic spinal-cord-injured patients
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Fecha
2023-06
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Chronic spinal cord injury affects several respiratory-function-related parameters, such
as a decrease in respiratory volumes associated with weakness and a tendency to fibrosis of the
perithoracic muscles, a predominance of vagal over sympathetic action inducing airway obstructions,
and a difficulty in mobilizing secretions. Altogether, these changes result in both restrictive and
obstructive patterns. Moreover, low pulmonary ventilation and reduced cardiovascular system
functionality (low venous return and right stroke volume) will hinder adequate alveolar recruitment
and low O2 diffusion, leading to a drop in peak physical performance. In addition to the functional
effects described above, systemic and localized effects on this organ chronically increase oxidative
damage and tissue inflammation. This narrative review describes both the deleterious effects of
chronic spinal cord injury on the functional effects of the respiratory system as well as the role of
oxidative damage/inflammation in this clinical context. In addition, the evidence for the effect
of general and respiratory muscular training on the skeletal muscle as a possible preventive and
treatment strategy for both functional effects and underlying tissue mechanisms is summarized.
Notas
Indexación: Scopus.
Palabras clave
Spinal Cord Injury, Lung, Inflammation, Oxidative Stress, Respiratory Muscle Training
Citación
Biology. Volume 12, Issue 6. June 2023. Article number 828
DOI
10.3390/biology12060828